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FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →

Melanotan I (Afamelanotide) Wholesale

α-MSH analogue (13 aa) — MC1R-selective agonist for melanocortin receptor research

Product Identity

CAS Number75921-69-6
Molecular FormulaC₇₈H₁₁₁N₂₁O₁₉
Molecular Weight~1,646.8 Da
AppearanceWhite to off-white lyophilized powder
Purity≥99% by HPLC
SolubilitySoluble in sterile water or PBS
Storage2–8°C, desiccated, protect from light
IdentificationESI-MS identity confirmation on each batch

Available Configurations

ConfigurationContentBest For
Standard Kit10 mg × 10 vialsProtocol validation; evaluation orders
CustomCustom mg × custom vialsOEM; private-label; protocol-specific

Research Background

Melanotan I (afamelanotide) is a 13-amino-acid analogue of α-melanocyte-stimulating hormone designed for increased stability and MC1 receptor selectivity. It is used in receptor-pharmacology and pigment-cell research as a selective melanocortin-1 receptor (MC1R) agonist alongside the broader-spectrum, cyclic analogue Melanotan II.

Proposed Mechanisms

MC1R agonismSelective activation of the melanocortin-1 receptor in receptor-binding studies
cAMP signallingMC1R-mediated cAMP pathway readouts in cultured melanocytes
Stability engineeringN-terminal and sequence modifications used in this analogue class to resist enzymatic degradation

Research Focus Areas

Receptor Pharmacology

MC1R selectivity and binding-characterisation studies

Pigment Cell Biology

Melanocyte-culture research models

Melanocortin Research

Comparison of linear vs cyclic α-MSH analogues

Quality Specifications

ParameterMethodCriterion
PurityHPLC at 214 nm, C18 column≥99.0% peak area
IdentityESI-MSDa
AppearanceVisual inspectionWhite to off-white lyophilized powder
Purity assayAmino acid analysis≥80% net peptide
Residual moistureKarl Fischer≤3%
SolubilityReconstitution testSoluble in sterile water or PBS

Tiered Wholesale Pricing

Kit sizeCodeList price
10 mg × 10 vialsMT1US$48

US$48–48 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).

VolumeDiscountFor
1 kitList priceEvaluation; competitive analysis
5+ kits10% offInitial portfolio expansion
20+ kits20% offMid-size distributors
50+ kits30% offRegional distributors

FAQ

What is the difference between Melanotan I and Melanotan II?

Melanotan I (afamelanotide) is a linear 13-amino-acid α-MSH analogue with selectivity for MC1R. Melanotan II is a cyclic 7-amino-acid analogue with a broader melanocortin receptor profile (including MC3R/MC4R) in receptor research.

Is this product for human use?

No. It is supplied strictly as a laboratory research reagent, FOR RESEARCH USE ONLY. It is not for human or veterinary use, and no human application, cosmetic use or clinical claim is made or implied.

What do you document for each batch?

A batch-specific COA with HPLC purity and mass-spectrometry identity, plus commercial invoice and packing list.

Which kit sizes are available?

10 mg × 10 vials as standard; custom vial sizes and OEM presentation are available on request.

All products are manufactured for laboratory research purposes only. Melanotan I is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.

Ready to Source Melanotan I?

Bulk pricing, tiered discounts up to 30%, COA with every order.

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