FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
ARA-290 Wholesale
Erythropoietin-derived 11-mer helix B peptide — tissue protection & repair via IRR agonism without erythropoietic effects, manufacturer-direct
Product Identity
| CAS Number | 1208243-50-8 |
| Sequence | H-Gln-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH |
| Amino Acids | 11 |
| Molecular Formula | C₅₁H₈₄N₁₆O₁₉ |
| Molecular Weight | ~1,258.4 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Tissue protection models; evaluation |
| Bulk Kit | 10 mg × 10 vials | Chronic neuropathy models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label; protocol-specific |
Research Background
ARA-290 is an 11-amino acid peptide engineered from the helix B domain of erythropoietin (EPO). The key innovation behind ARA-290 is its receptor selectivity: it activates the Innate Repair Receptor (IRR, also known as the β-common receptor/CD131 heterodimer) but does not bind the classical EPO receptor (EPO-R). This receptor discrimination separates tissue-protective signaling from erythropoietic signaling — in research models, ARA-290 demonstrates tissue protection and anti-inflammatory effects without elevating hematocrit.
Proposed Mechanisms
Research Focus Areas
Nerve fiber density preservation; pain threshold normalization
Infarct size reduction; caspase-3 suppression
Chronic wound models; diabetic ulcer re-epithelialization
Acute kidney injury models; tubular cell survival
Microglial activation modulation; IL-1β/TNF-α suppression
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~1,258.4 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 10 mg × 10 vials | RA10 | US$66 |
US$66–66 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is ARA-290 and how does it differ from EPO?
ARA-290 is an 11-amino acid peptide derived from the helix B domain of erythropoietin. It selectively activates the Innate Repair Receptor (IRR/CD131) without binding the classical EPO receptor — providing tissue protection without erythropoiesis (no increase in hematocrit). This receptor selectivity is the defining feature.
What research applications is ARA-290 used for?
Primarily neuroprotection (small fiber neuropathy, peripheral nerve injury models), cardiac ischemia-reperfusion injury reduction, wound healing (chronic and diabetic ulcer models), renal protection, and neuroinflammation research.
Why doesn't ARA-290 affect red blood cell production?
EPO's tissue-protective and erythropoietic activities are mediated by distinct receptor complexes. ARA-290 was specifically engineered to only activate the IRR/CD131 heterodimer (tissue protection) and not the EPO-R homodimer (erythropoiesis).
How should ARA-290 be stored?
Lyophilized powder: 2–8°C, desiccated, 24-month stability. After reconstitution in sterile water or PBS, aliquot single-use portions and store at -20°C. Avoid freeze-thaw cycles.
What documentation is included with ARA-290?
Batch-specific COA (HPLC purity, ESI-MS identity confirmation), commercial invoice, and packing list. Full chromatogram and MS spectrum available on request.
All products are manufactured for laboratory research purposes only. ARA-290 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source ARA-290?
Bulk pricing, tiered discounts up to 30%, COA with every order.