FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
TB-500 Wholesale
Thymosin Beta-4 fragment (17-43) — G-actin sequestration research tool, batch-documented, manufacturer-direct
Product Identity
| CAS Number | 77591-33-4 |
| Sequence | Thymosin Beta-4 fragment (17-43) with actin-binding domain |
| Molecular Weight | ~4,963 Da (full Tβ4); fragment MW fragment-dependent |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Freely soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Factory-directShenzhen, China
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Most research protocols |
| Bulk Kit | 10 mg × 10 vials | High-throughput; repeat buyers |
| BPC-157 + TB-500 Stack | 5mg + 5mg × 10 vials | Combined tissue repair research |
| Custom | Custom mg × custom vials | OEM; protocol-specific |
Research Background
Thymosin Beta-4 is a 43-amino acid peptide ubiquitously expressed in mammalian cells. TB-500 is its synthetic fragment containing the G-actin binding domain — making it a critical tool for cell migration and tissue repair research.
Proposed Mechanisms
Research Focus Areas
Accelerated closure; reduced scar formation (collagen III:I ratio)
Keratinocyte & endothelial migration via G-actin remodeling
Endothelial differentiation; capillary tube formation
Anagen phase entry promotion
Reduced infarct size; improved function post-MI
Reduced NF-κB activation and TNF-α expression
Neurite outgrowth; excitotoxic damage protection
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm | ≥99.0% peak area |
| Identity (MW) | ESI-MS | Confirmed ±1.0 Da |
| Appearance | Visual | White to off-white powder |
| Peptide Content | AAA / nitrogen | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
| Solubility | Sterile water test | Clear solution |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | TB5 | US$79 |
| 10 mg × 10 vials | TB10 | US$146 |
US$79–146 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
How does TB-500 differ from BPC-157 mechanistically?
TB-500 works via G-actin sequestration — binding monomeric actin to regulate cytoskeletal dynamics and cell migration. BPC-157 works via VEGF-mediated angiogenesis, GH receptor upregulation, and NO modulation. They are complementary: TB-500 mobilizes cells into wound sites; BPC-157 builds blood supply and growth factor environment. This is the mechanistic basis for their frequent combined use.
What's the recommended storage?
2–8°C, desiccated, protect from light. Powder is hygroscopic — reseal vials after opening. Stable 12–24 months. Post-reconstitution: aliquot into single-use portions in polypropylene tubes, freeze at -20°C. Avoid freeze-thaw cycles.
Can you provide full-length Thymosin Beta-4 (43-mer)?
Yes — available on request for protocols requiring the complete 43-amino acid sequence. Higher synthesis complexity and price vs. the TB-500 fragment. Contact us with your requirements.
Is TB-500 the same as Thymosin Beta-4?
Not exactly. TB-500 is the synthetic 17-43 fragment of Tβ4, containing the actin-binding domain. The full 43-mer may have additional N-terminal activities. For most tissue repair research, the TB-500 fragment is sufficient — it's the most commonly studied form.
All products are manufactured for laboratory research purposes only. TB-500 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source TB-500?
Tiered discounts up to 30%. COA with every order. Combined BPC-157 + TB-500 ordering available.