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BPC-157 vs TB-500
These are the two most-bought repair-research peptides in the catalogue, and they are frequently confused because both are studied in tissue-repair models. Their molecular origins are unrelated: BPC-157 is a gastric-juice-derived pentadecapeptide, while TB-500 is derived from thymosin β4, an actin-binding protein.
Side-by-side comparison
| Parameter | BPC-157 | TB-500 |
|---|---|---|
| Origin | Partial sequence of BPC (Body Protection Compound) from human gastric juice | Derived from thymosin β4, the actin-sequestering protein |
| Length | 15 amino acids (pentadecapeptide) | Thymosin β4-derived fragment |
| Catalogue CAS / MW | 137525-51-0 · ~1,419.5 Da | 77591-33-4 · ~4,963.5 Da (as listed in our catalogue — see note below) |
| Catalogue sequence | H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH | Listed on the product page and in the downloadable dataset |
| Mechanism class in the literature | VEGF-linked angiogenesis signalling, focal-adhesion-kinase pathway, nitric-oxide system modulation; studied in GI-protection and tendon/ligament repair models | Actin sequestration and cell-migration research; studied in wound-healing and angiogenesis models |
| Catalogue kit sizes | 5, 10 and 20 mg × 10 vials | 5 and 10 mg × 10 vials |
| Pre-formulated combination | Available with TB-500 in one vial (BB10 / BB20 / BB30) | Available with BPC-157 in one vial, and with GHK-Cu in the GLOW blend |
Identity data and sequences as published on each product page and in the downloadable reference dataset. Mechanism descriptions follow published research on each peptide. Catalogue CAS/MW values are reproduced unchanged — including the flag on the thymosin β4 mass — so nothing is silently altered.
How to choose between them
Pick by mechanism, not by popularity
If the readout is angiogenesis, VEGF expression or focal-adhesion signalling, BPC-157's literature is the match. If the readout is cell migration or actin cytoskeleton behaviour, use TB-500.
Beware the mass check on thymosin-β4-derived products
Catalogue CAS 77591-33-4 corresponds to full-length thymosin β4 (~4,963 Da), whereas short actin-binding fragments of the same protein appear at ~889 Da. Confirm which material a vendor is actually supplying with the COA mass spectrum before relying on a published protocol.
Consider the blended presentation for combined protocols
If a design calls for both peptides, the co-lyophilized BPC-157 + TB-500 kit removes a handling step and ships with component-level analytical documentation.
Products in this comparison
| Product | List price (per kit of 10 vials) |
|---|---|
| BPC-157 | US$40–85 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
| TB-500 | US$79–146 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
| Thymosin Beta-4 | US$79–146 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
| BPC-157 + TB-500 blend | US$98–265 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
| GLOW blend (with GHK-Cu) | US$180–180 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
FAQ
Are BPC-157 and TB-500 the same kind of molecule?
No. BPC-157 is a 15-amino-acid peptide derived from a gastric protein; TB-500 is derived from thymosin β4, an intracellular actin-binding protein. They are studied in overlapping repair models but through different mechanism classes.
Can they be supplied in one vial?
Yes. Our BB10, BB20 and BB30 kits contain BPC-157 and TB-500 co-lyophilized at matched ratios, with analytical documentation for each component batch.
Why does the catalogue list TB-500 at ~4,963 Da?
Because the CAS number 77591-33-4 listed for this product corresponds to full-length thymosin β4. Shorter actin-binding fragments of the same protein appear at around 889 Da. We publish the catalogue figure unchanged and flag the discrepancy here so buyers confirm the material against the batch COA mass spectrum.
What documentation is included?
A batch-specific COA with HPLC purity and ESI-MS identity for each kit, plus commercial invoice and packing list. Full chromatograms and spectra are available on request.
Need a quote for this group?
Component specifications, batch COAs and volume pricing for the whole cluster — quoted within one business day.