FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Thymosin Beta-4 Wholesale
Full-length thymosin β4 — 43-amino acid actin-sequestering polypeptide for tissue regeneration research, manufacturer-direct
Product Identity
| CAS Number | 77591-33-4 |
| Sequence | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-OH |
| Amino Acids | 43 |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Molecular Weight | ~4,963.5 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Tissue regeneration models; evaluation |
| Custom | Custom mg × custom vials | OEM; private-label; bulk research |
Research Background
Thymosin Beta-4 is a naturally occurring 43-amino acid polypeptide found in virtually all mammalian cells. It was originally identified as the thymic hormone responsible for T-cell maturation, but subsequent research revealed its primary intracellular function: G-actin sequestration. By maintaining the cellular actin monomer pool, Thymosin Beta-4 regulates cytoskeletal dynamics critical for cell migration, wound healing, and angiogenesis. Unlike its synthetic fragment TB-500, full-length Thymosin Beta-4 retains the complete N-terminal actin-binding domain and C-terminal regulatory regions, offering the full biological activity of the native protein.
Proposed Mechanisms
Research Focus Areas
Endothelial cell migration & capillary tube formation in wound models
Keratinocyte migration; accelerated re-epithelialization
Cardiomyocyte survival post-ischemia; Akt activation
NF-κB suppression; M2 macrophage polarization
Dermal papilla cell activation; anagen phase promotion
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~4,963.5 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | TB5 | US$79 |
| 10 mg × 10 vials | TB10 | US$146 |
US$79–146 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is the difference between TB-500 and Thymosin Beta-4?
TB-500 is the synthetic N-terminal fragment (Ac-LKKTETQ, ~889 Da) of the full 43-amino acid Thymosin Beta-4 protein. TB-500 retains the core actin-binding motif but lacks the full C-terminal regulatory sequence. Thymosin Beta-4 is the complete native protein with broader biological activity including additional binding domains and post-translational interaction sites.
What research applications is Thymosin Beta-4 used for?
Primarily wound healing, angiogenesis, cardiac protection, and tissue regeneration research. Its actin-sequestering activity makes it a key tool in cytoskeletal dynamics studies. Also investigated in dermal repair, corneal healing, and hair follicle biology.
How should Thymosin Beta-4 be stored and reconstituted?
Reconstitute with sterile water or PBS (pH 7.0–7.4). The full-length protein is slightly more complex to handle than TB-500 due to its larger size. Aliquot single-use portions and store at -20°C. Avoid freeze-thaw cycles. Lyophilized powder: 24-month stability at 2–8°C.
Is Thymosin Beta-4 the same as Thymosin α1?
No. Thymosin α1 (28 amino acids, ~3,108 Da) and Thymosin β4 (43 amino acids, ~4,964 Da) are distinct proteins with different biological roles. Thymosin α1 is primarily immunomodulatory, while Thymosin β4 is primarily involved in actin dynamics and tissue repair.
Do you offer custom Thymosin Beta-4 configurations?
Yes. Standard kit is 5mg × 10 vials. Custom mg per vial and vial count available for qualifying wholesale orders. Contact us for a custom quotation including private-label options.
All products are manufactured for laboratory research purposes only. Thymosin Beta-4 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Thymosin Beta-4?
Bulk pricing, tiered discounts up to 30%, COA with every order.