FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
VIP (Vasoactive Intestinal Peptide) Wholesale
28-amino-acid neuroendocrine peptide studied in vascular, gastrointestinal and circadian-signalling models
Product Identity
| CAS Number | 37221-79-7 |
| Molecular Formula | C₁₄₇H₂₃₇N₄₃O₄₃S |
| Molecular Weight | ~3,326.8 Da |
| Amino Acids | 28 |
| Sequence | HSDAVFTDNYTRLRKQMAVKKYLNSILN |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Storage | 2–8°C, desiccated, protect from light |
| Identification | ESI-MS identity confirmation on each batch |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Protocol validation; evaluation orders |
| Bulk Kit | 40 mg × 10 vials | High-throughput research; repeat buyers |
| Custom | Custom mg × custom vials | OEM; private-label; protocol-specific |
Research Background
VIP is a 28-amino-acid peptide of the secretin/glucagon superfamily, acting through the class-B GPCRs VPAC1 and VPAC2. It is the standard reference agonist in research on smooth-muscle relaxation and vascular tone, intestinal secretion, and suprachiasmatic-nucleus circadian signalling. Because it is rapidly cleaved in vivo, published protocols commonly compare it with VPAC-selective analogues to separate receptor-subtype effects from clearance effects.
Proposed Mechanisms
Research Focus Areas
Peptidergic control of pituitary and hypothalamic signalling
Vasodilation, secretion and motility models
SCN entrainment and clock-output studies
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity | ESI-MS | Da |
| Appearance | Visual inspection | White to off-white lyophilized powder |
| Purity assay | Amino acid analysis | ≥80% net peptide |
| Residual moisture | Karl Fischer | ≤3% |
| Solubility | Reconstitution test | Soluble in sterile water or PBS |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | VIP5 | US$79 |
| 10 mg × 10 vials | VIP10 | US$146 |
US$79–146 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is VIP used for in research?
VIP is used as the reference agonist in VPAC1/VPAC2 signalling studies, smooth-muscle relaxation and vascular-tone models, intestinal secretion research, and suprachiasmatic-nucleus circadian work.
What is the CAS number and molecular weight of VIP?
The catalogue lists CAS 37221-79-7 with a molecular weight of approximately 3,326.8 Da for the 28-amino-acid peptide; the sequence is stated on the specification table and on each Certificate of Analysis.
Is VIP human or porcine sequence in this catalogue?
The 28-amino-acid sequence listed here matches the human/porcine form, which differ only at position 5 in some species variants. Confirm the exact sequence printed on the COA for your batch.
How should VIP be stored?
Lyophilized powder is shipped and stored at 2–8 °C, desiccated and protected from light. Reconstituted solution stability is protocol-dependent and should be established in your own laboratory.
What kit sizes and bulk pricing are available?
VIP is supplied as 5 mg × 10 vials and 10 mg × 10 vials, with tiered wholesale discounts from 10% at 5+ kits to 30% at 50+ kits; custom kit configurations are available for OEM projects.
All products are manufactured for laboratory research purposes only. MOTS-c is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
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Bulk pricing, tiered discounts up to 30%, COA with every order.