FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Epithalon Wholesale
Ala-Glu-Asp-Gly tetrapeptide — telomerase activation & replicative lifespan research, manufacturer-direct
Product Identity
| CAS Number | 307297-39-8 |
| Sequence | Ala-Glu-Asp-Gly-OH |
| Amino Acids | 4 |
| Molecular Formula | C₁₄H₂₂N₄O₉ |
| Molecular Weight | ~390.4 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Longevity research; evaluation |
| Bulk Kit | 30 mg × 10 vials | Chronic aging models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide designed by Prof. Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. Derived from epithalamin — a polypeptide complex extracted from bovine pineal glands — through structure-activity optimization to identify the minimal active sequence. The resulting tetrapeptide has become one of the most studied peptide bioregulators in longevity research, with published data demonstrating telomerase activation via hTERT gene expression and telomere length preservation.
Proposed Mechanisms
Research Focus Areas
hTERT gene expression → telomere length maintenance in somatic cells
Cellular senescence delay; population doubling increase
Pineal peptide extract-derived → circadian and neuroendocrine modulation
Melatonin rhythm preservation; oxidative stress marker reduction
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~390.4 ± 0.5 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 10 mg × 10 vials | ET10 | US$64 |
| 50 mg × 10 vials | ET50 | US$185 |
US$64–185 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is the evidence for Epithalon's effect on telomeres?
Khavinson et al. demonstrated that Epithalon activates hTERT gene expression in human somatic cell cultures, leading to telomere length maintenance and extended replicative lifespan. The proposed mechanism involves chromatin remodeling at the hTERT promoter region.
How does Epithalon relate to epithalamin?
Epithalamin is a crude polypeptide complex from bovine pineal glands. Epithalon (Ala-Glu-Asp-Gly) is the synthetic tetrapeptide capturing the active sequence identified through systematic fragmentation of epithalamin.
Is Epithalon the same as Epitalon?
Yes. 'Epithalon,' 'Epitalon,' and 'AEDG peptide' all refer to the same Ala-Glu-Asp-Gly tetrapeptide. Name variations arise from transliteration differences from Russian (Эпиталон).
What is the pineal peptide hypothesis of aging?
The hypothesis proposes that the pineal gland produces peptide bioregulators coordinating circadian rhythms, neuroendocrine function, and cellular maintenance. Age-related pineal decline → reduced signaling → accelerated aging. Epithalon is proposed to restore this signaling deficiency.
What purity specification applies to Epithalon?
≥99% by HPLC at 214 nm. As a simple tetrapeptide, synthesis is straightforward but the C-terminal glycine requires careful handling to avoid racemization. ESI-MS and amino acid analysis in every COA.
All products are manufactured for laboratory research purposes only. Epithalon is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Epithalon?
Bulk pricing, tiered discounts up to 30%, COA with every order.