FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Semax Wholesale
ACTH(4–7)-Pro-Gly-Pro heptapeptide — BDNF upregulation & neuroprotection research, manufacturer-direct
Product Identity
| CAS Number | 80714-61-0 |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro-OH |
| Amino Acids | 7 (ACTH(4-7) + Pro-Gly-Pro C-terminal) |
| Molecular Formula | C₃₇H₅₁N₉O₁₀S |
| Molecular Weight | ~813.9 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Neuroprotection studies; evaluation |
| Bulk Kit | 30 mg × 10 vials | Chronic cognitive models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
Semax is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It consists of the ACTH(4–7) fragment (Met-Glu-His-Phe) — the active core of adrenocorticotropic hormone that mediates neurotrophic effects without steroidogenic activity — extended with a C-terminal Pro-Gly-Pro tripeptide. Semax is the most extensively characterized nootropic peptide in the literature, with documented effects on BDNF and NGF expression, cognitive function, and neuroprotection across multiple paradigms.
Proposed Mechanisms
Research Focus Areas
Ischemia/hypoxia models — neuronal survival enhancement
Learning & memory consolidation in rodent models
Neurotrophin expression — synaptic plasticity support
Post-ischemic neurological function improvement
Retinal ganglion cell survival in glaucoma models
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~813.9 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Met Oxidation | HPLC-MS | Met(O) ≤ 1% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | XA5 | US$45 |
| 10 mg × 10 vials | XA10 | US$58 |
US$45–58 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is Semax and how does it relate to ACTH?
Semax is a synthetic heptapeptide based on ACTH(4–7), the N-terminal fragment of ACTH that mediates neurotrophic effects without adrenal steroidogenesis. The C-terminal Pro-Gly-Pro extension confers metabolic stability and CNS penetration.
What is the mechanism of Semax's cognitive effects?
Semax primarily upregulates BDNF and NGF via melanocortin receptor activation. Elevated neurotrophins support synaptic plasticity, neuronal survival, and cognitive function. Additional effects include anti-inflammatory microglial modulation and improved cerebral blood flow.
How does the Pro-Gly-Pro extension work?
The C-terminal PGP tripeptide protects from carboxypeptidase degradation and enhances blood-brain barrier penetration. The Pro-Gly-Pro sequence itself has reported glyproline activity that may contribute to neuroprotection.
How does Semax differ from Selank?
Both are Russian-developed nootropics with distinct mechanisms. Semax (ACTH-derived) → melanocortin receptors → BDNF/NGF → cognition. Selank (tuftsin-derived) → GABAergic/dopaminergic → anxiolysis. Complementary: Semax for cognition, Selank for anxiety.
What purity and QC is provided for Semax?
≥99% HPLC with ESI-MS identity. Special QC: Met(O) content ≤ 1% (N-terminal methionine is oxidation-sensitive). Batch-specific COA included.
All products are manufactured for laboratory research purposes only. Semax is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Semax?
Bulk pricing, tiered discounts up to 30%, COA with every order.