FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Selank Wholesale
Tuftsin-derived heptapeptide — GABAergic/dopaminergic anxiolytic without sedation, manufacturer-direct
Product Identity
| CAS Number | 129954-34-1 |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH |
| Amino Acids | 7 (tuftsin analogue + Pro-Gly-Pro) |
| Molecular Formula | C₃₃H₅₇N₁₁O₉ |
| Molecular Weight | ~751.9 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Anxiolytic research; evaluation |
| Bulk Kit | 30 mg × 10 vials | Chronic anxiety models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
Selank is a synthetic heptapeptide sharing the same Pro-Gly-Pro C-terminal extension design as Semax. While Semax derives from ACTH, Selank derives from tuftsin (Thr-Lys-Pro-Arg) — a natural immunomodulatory tetrapeptide. The Pro-Gly-Pro tail transforms tuftsin from a pure immune peptide into a dual-function molecule engaging the immune-neural interface while enabling CNS penetration. Selank's primary research application is anxiolysis through GABAergic and dopaminergic modulation — producing anxiety reduction without sedation, cognitive impairment, or dependence liability.
Molecular Notes
- Heptapeptide Thr-Lys-Pro-Arg-Pro-Gly-Pro: the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) extended C-terminally by Pro-Gly-Pro, an extension introduced in the Russian regulatory-peptide literature to increase protease resistance.
- Its two research streams are distinct: GABA-related cell experiments on one side, and human-serum assays showing inhibition of enkephalin-degrading enzymes on the other.
- Reported anxiolytic-like and BDNF-related findings come from animal models — in rat hippocampus, Bdnf mRNA and BDNF protein levels were reported to rise after administration at 250–500 µg/kg.
- Human work is limited and measured different endpoints: a 2020 study of 52 healthy participants reported short-term resting-state connectivity differences (5 and 20 minutes after administration), not cognitive or anxiolytic benefit.
- The Pro-Gly-Pro tail is shared with Semax as a stability design element only — the two peptides derive from unrelated precursors (tuftsin vs ACTH(4-7)).
Proposed Mechanisms
Research Focus Areas
GABAergic modulation — anxiety reduction without sedation in models
Learning & memory preservation under stress conditions
Tuftsin-derived immunomodulation → CNS effects
HPA axis modulation; cortisol reduction in stress models
Tuftsin-mediated immune enhancement against viral challenges
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~751.9 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | SK5 | US$45 |
| 10 mg × 10 vials | SK10 | US$64 |
US$45–64 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
How does Selank compare to benzodiazepines?
Selank produces anxiolytic effects through GABAergic modulation without sedation, amnesia, tolerance, or withdrawal. Rather than directly agonizing GABA-A, Selank modulates endogenous GABA tone — a more subtle mechanism preserving cognitive function and alertness.
What is the connection between tuftsin and Selank?
Tuftsin (Thr-Lys-Pro-Arg) is a natural splenic tetrapeptide that activates macrophages. Selank adds Pro-Gly-Pro to tuftsin, creating dual functionality: immunomodulation + CNS delivery. This immune-neural bridge is a defining feature of Selank's pharmacology.
How does Selank differ from Semax?
Both are PGP-extended heptapeptides but from different parents. Semax (ACTH-derived) → melanocortin → BDNF/NGF → cognition. Selank (tuftsin-derived) → GABA/dopamine → anxiolysis. Complementary: Semax for cognition, Selank for anxiety.
Does Selank cause sedation?
No — a significant distinction from benzodiazepines. In animal models, Selank produces anxiolytic effects at doses that do not cause sedation, motor impairment, or amnesia. Attributed to modulation of endogenous GABA tone rather than direct receptor agonism.
What purity and QC is provided?
≥99% HPLC purity, ESI-MS identity, amino acid analysis. Pro-Gly-Pro extension verified by MS/MS fragmentation. Batch-specific COA included.
What is the Selank sequence and where does it come from?
Selank is H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH: the tuftsin tetrapeptide of the immunoglobulin G heavy chain extended by Pro-Gly-Pro, a modification introduced to improve resistance to peptidases.
What do the human studies of Selank actually measure?
Short-term CNS endpoints. A 2020 study of 52 healthy participants measured resting-state functional connectivity at 5 and 20 minutes after administration; it did not test anxiolytic or cognitive benefit, and no human-application claim is made here.
All products are manufactured for laboratory research purposes only. Selank is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Selank?
Bulk pricing, tiered discounts up to 30%, COA with every order.