FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Leuphasyl Wholesale
Pentapeptide-18 — enkephalin analogue for fine line & calcium channel modulation research, manufacturer-direct
Product Identity
| CAS Number | — (Pentapeptide-18) |
| Sequence | Tyr-D-Ala-Gly-Phe-Leu-OH |
| Amino Acids | 5 (D-Ala² substitution) |
| Molecular Formula | C₃₃H₄₅N₅O₈ |
| Molecular Weight | ~623.7 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water; cosmetic formulation-compatible |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Fine line models; evaluation |
| Bulk Kit | 50 mg × 10 vials | Product development; pilot batches |
| Custom | Custom mg × custom vials | OEM; private-label cosmetics |
Research Background
Leuphasyl (Pentapeptide-18) is a synthetic enkephalin analogue pentapeptide featuring a D-Ala² substitution that confers resistance to enzymatic degradation. Unlike Snap-8 and Argireline — which target SNARE-mediated vesicle docking — Leuphasyl operates through a fundamentally different mechanism: δ-opioid receptor (DOR) agonism leading to modulation of voltage-gated calcium channels. This reduces neuronal calcium influx, which in turn decreases acetylcholine release at the neuromuscular junction.
Proposed Mechanisms
Research Focus Areas
Periorbital and perioral fine line reduction in topical models
Calcium channel-mediated smooth muscle relaxation
Enkephalin receptor-mediated neuromuscular signaling
Topical delivery of enkephalin analogue peptides
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~623.7 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is Leuphasyl and how does it work?
Leuphasyl (Pentapeptide-18) is a synthetic enkephalin analogue pentapeptide with a D-Ala² substitution. It activates δ-opioid receptors, which modulate voltage-gated calcium channels — reducing calcium influx and consequently decreasing ACh release at the NMJ.
How does Leuphasyl differ from Snap-8 and Argireline?
Mechanistically: Leuphasyl targets opioid receptors → calcium channel modulation. Snap-8 and Argireline target SNARE complex → vesicle docking inhibition. Leuphasyl is preferred for fine line models; Snap-8/Argireline for deeper expression lines.
What does the D-Ala² substitution do?
The D-Ala² substitution replaces natural L-Ala with D-Ala, conferring resistance to aminopeptidase degradation. This significantly extends half-life compared to natural enkephalins, making it viable for topical formulation research.
Is Leuphasyl stable in topical formulations?
Yes. As a short pentapeptide (~623.7 Da), Leuphasyl shows good stability at pH 5.0–7.0. Small size facilitates stratum corneum penetration in topical models.
What is the standard purity specification?
≥99% by HPLC with ESI-MS identity. The D-Ala² substitution is verified by chiral amino acid analysis. Batch-specific COA included.
All products are manufactured for laboratory research purposes only. Leuphasyl is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Leuphasyl?
Bulk pricing, tiered discounts up to 30%, COA with every order.