FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Snap-8 Wholesale
Acetyl octapeptide-3 — SNAP-25 SNARE complex inhibitor for expression line research, manufacturer-direct
Product Identity
| CAS Number | — (Acetyl Octapeptide-3) |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Amino Acids | 8 (N-terminal acetyl, C-terminal amide) |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular Weight | ~1,073.2 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water; cosmetic formulation-compatible |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Formulation research; evaluation |
| Bulk Kit | 50 mg × 10 vials | Product development; pilot batches |
| Custom | Custom mg × custom vials | OEM; private-label cosmetics |
Research Background
Snap-8 (Acetyl Octapeptide-3) is an N-terminal acetylated, C-terminal amidated octapeptide designed to interfere with SNARE complex assembly at the presynaptic membrane. By mimicking the N-terminal domain of SNAP-25 — a critical SNARE protein — Snap-8 competes for binding sites within the ternary SNARE complex (SNAP-25/syntaxin/VAMP). This competition reduces the efficiency of synaptic vesicle docking and fusion, leading to decreased acetylcholine release at the neuromuscular junction.
Proposed Mechanisms
Research Focus Areas
SNARE complex inhibition → reduced neurotransmitter release at NMJ
Periorbital wrinkle reduction in topical formulation models
Frontalis muscle relaxation via SNAP-25 competition
Topical peptide delivery systems for cosmetic research
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~1,073.2 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 10 mg × 10 vials | NP8 10 | US$45 |
US$45–45 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
How does Snap-8 work in anti-wrinkle research?
Snap-8 mimics the N-terminal domain of SNAP-25, a protein essential for SNARE complex assembly. By competing with native SNAP-25, it reduces synaptic vesicle docking efficiency → less ACh released at NMJ → muscle fibers relax → expression lines reduced in topical research.
How does Snap-8 differ from Argireline?
Both target neurotransmitter release through different mechanisms. Argireline prevents formation of the ternary SNARE complex. Snap-8 specifically targets the SNAP-25 binding site within the complex. In research they are sometimes combined for multi-target effects.
Is Snap-8 stable in topical formulations?
Yes. N-terminal acetylation and C-terminal amidation enhance metabolic stability and skin penetration. Soluble in standard cosmetic base formulations at pH 5.0–7.0.
Can Snap-8 and Leuphasyl be used together?
Yes — this is a common research combination. Snap-8 targets SNARE complex assembly, while Leuphasyl acts through opioid receptor-mediated calcium channel modulation. Complementary mechanisms.
What is the standard purity for Snap-8?
≥99% by HPLC with ESI-MS identity. Batch-specific COA included. For cosmetic-grade bulk orders, lower purity grades may be available — contact us for specifications.
All products are manufactured for laboratory research purposes only. Snap-8 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Snap-8?
Bulk pricing, tiered discounts up to 30%, COA with every order.