FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Argireline Wholesale
Acetyl hexapeptide-8 — SNARE complex formation inhibitor for expression line research, manufacturer-direct
Product Identity
| CAS Number | 616204-22-9 |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ |
| Amino Acids | 6 (N-terminal acetyl, C-terminal amide) |
| Molecular Formula | C₃₄H₆₀N₁₄O₁₂S |
| Molecular Weight | ~889.0 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water; cosmetic formulation-compatible |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | Anti-wrinkle formulation research; evaluation |
| Bulk Kit | 50 mg × 10 vials | Product development; pilot production |
| Custom | Custom mg × custom vials | OEM; private-label cosmetics |
Research Background
Argireline (Acetyl Hexapeptide-8) is the most extensively studied anti-wrinkle peptide in cosmetic research. It functions as a competitive inhibitor of SNARE complex formation — the protein machinery that mediates synaptic vesicle docking and neurotransmitter release. By mimicking the N-terminal domain of SNAP-25, Argireline prevents formation of the ternary SNARE complex, reducing acetylcholine release at the neuromuscular junction. This produces a topical 'botulinum-mimetic' effect in research models.
Proposed Mechanisms
Research Focus Areas
SNARE complex inhibition → reduced vesicle docking → decreased ACh release
Frontalis muscle relaxation in topical formulation models
Periorbital wrinkle severity reduction in split-face studies
Non-invasive neurotransmitter modulation for cosmetic research
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~889.0 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
How does Argireline work in anti-wrinkle research?
Argireline mimics the N-terminal domain of SNAP-25, competitively inhibiting formation of the SNARE complex. Without a functional SNARE complex, synaptic vesicles cannot dock — ACh release is reduced, muscle fibers relax, and expression lines diminish in topical models.
What distinguishes Argireline from Snap-8?
Both target SNARE-mediated neurotransmitter release. Argireline prevents initial formation of the ternary SNARE complex. Snap-8 specifically targets the SNAP-25 binding site within an already-assembling complex. Argireline is the most-studied peptide in this class.
Is Argireline considered a 'topical Botox'?
In research terminology, Argireline is described as a 'topical botulinum-mimetic' because both reduce ACh release at the NMJ. However, mechanisms differ: botulinum toxin proteolytically cleaves SNARE proteins, while Argireline competitively inhibits SNARE assembly. Non-invasive topical delivery is the key distinction.
What is the optimal pH for Argireline in formulations?
Stable at pH 5.0–7.0. N-terminal acetylation and C-terminal amidation protect against exopeptidase degradation. Avoid strongly acidic (pH < 4) or alkaline (pH > 8) conditions.
What documentation is provided with Argireline?
Batch-specific COA: HPLC purity (≥99%), ESI-MS identity, peptide content by amino acid analysis. Commercial invoice and packing list included. Full analytical package for bulk orders.
All products are manufactured for laboratory research purposes only. Argireline is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Argireline?
Bulk pricing, tiered discounts up to 30%, COA with every order.