FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Matrixyl Wholesale
Palmitoyl pentapeptide-4 — collagen fragment signal peptide for extracellular matrix research, manufacturer-direct
Product Identity
| CAS Number | 214047-00-4 |
| Sequence | Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH |
| Amino Acids | 5 (N-terminal palmitoyl) |
| Molecular Formula | C₃₉H₇₅N₇O₁₀ |
| Molecular Weight | ~803.9 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Lipid-soluble; limited aqueous solubility |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 10 mg × 10 vials | ECM research; formulation evaluation |
| Bulk Kit | 50 mg × 10 vials | Product development; pilot batches |
| Custom | Custom mg × custom vials | OEM; private-label cosmetics |
Research Background
Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide designed around the concept of 'matrikine' signaling — using small peptide fragments of extracellular matrix proteins to stimulate the skin's own repair mechanisms. It consists of the pentapeptide Lys-Thr-Thr-Lys-Ser conjugated to a palmitic acid (C16) chain for enhanced skin penetration. Unlike neurotransmitter-targeting peptides (Argireline, Snap-8), Matrixyl addresses expression lines from the structural side — rebuilding dermal matrix components rather than inhibiting muscle contraction.
Proposed Mechanisms
Research Focus Areas
Procollagen I and III upregulation in dermal fibroblast models
Fibronectin and elastin production stimulation
Dermal matrix regeneration in photoaged skin models
Increased dermal density and elasticity in clinical research
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~803.9 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
How does Matrixyl differ from other cosmetic peptides?
Matrixyl targets the structural extracellular matrix (collagen, elastin, fibronectin synthesis) rather than neuromuscular signaling. While Argireline/Snap-8 reduce lines by inhibiting contraction, Matrixyl rebuilds dermal matrix components through matrikine signaling.
What is the purpose of the palmitoyl group?
N-terminal palmitoyl (C16) dramatically enhances stratum corneum penetration by partitioning into the lipid-rich intercellular matrix, and anchors the peptide at the cell membrane, prolonging fibroblast receptor interaction. Without it, dermal delivery would be negligible.
What does 'matrikine' mean?
Matrikines are peptide fragments released during ECM degradation that signal cells to initiate repair. Matrixyl mimics this by presenting a collagen-derived peptide sequence to fibroblasts — 'tricking' cells into believing ECM damage has occurred, triggering repair.
Is Matrixyl compatible with other cosmetic peptides?
Yes. Matrixyl's ECM-building mechanism is complementary to neurotransmitter-targeting peptides (Argireline, Snap-8) and copper peptides (GHK-Cu). Multi-peptide formulations combining matrikine + neurotransmitter inhibitor + carrier peptide are common research strategies.
What purity is Matrixyl supplied at?
≥99% by HPLC at 214 nm. Palmitoylation efficiency (>98%) verified by HPLC with ELSD detection. Batch-specific COA included.
All products are manufactured for laboratory research purposes only. Matrixyl is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source Matrixyl?
Bulk pricing, tiered discounts up to 30%, COA with every order.