FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
AOD-9604 Wholesale
hGH C-terminal fragment 177–191 — selective lipolytic peptide without IGF-1 elevation, manufacturer-direct
Product Identity
| CAS Number | 221231-10-3 |
| Sequence | H-YLRIVQCRSVEGSCGF-OH (cyclic, Cys⁷–Cys¹⁴ disulfide) |
| Amino Acids | 16 (cyclic via disulfide bond) |
| Molecular Formula | C₇₈H₁₂₃N₂₃O₂₃S₂ |
| Molecular Weight | ~1,815.1 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 2 mg × 10 vials | Lipolysis models; evaluation orders |
| Bulk Kit | 5 mg × 10 vials | Chronic metabolic models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label; protocol-specific |
Research Background
AOD-9604 is the synthetic C-terminal fragment of human Growth Hormone, spanning amino acids 177 through 191. This 16-amino acid cyclic peptide retains the lipolytic domain of hGH while lacking the N-terminal region required for Growth Hormone Receptor (GHR) binding and subsequent IGF-1 induction. The result is a precision tool for studying adipose tissue lipolysis without the confounding effects of the GH/IGF-1 axis — including insulin resistance, IGF-1 elevation, and growth-promoting activity.
Proposed Mechanisms
Research Focus Areas
Selective fat mobilization via β3-adrenergic pathway without IGF-1 elevation
Chondrocyte proliferation & proteoglycan synthesis in osteoarthritis models
Fat oxidation during caloric deficit; glucose homeostasis preservation
Fat mass reduction without lean mass loss in rodent models
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~1,815.1 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Disulfide Bond | Ellman's test | Confirmed cyclic (Cys⁷–Cys¹⁴) |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | 5AD | US$106 |
| 10 mg × 10 vials | 10AD | US$185 |
US$106–185 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is AOD-9604 and how does it relate to HGH?
AOD-9604 is the synthetic C-terminal fragment (amino acids 177-191) of human Growth Hormone. It retains the lipolytic domain of hGH without the GHR binding region — meaning it stimulates fat breakdown without raising IGF-1 levels.
Does AOD-9604 affect blood glucose like full HGH?
No. Unlike full-length hGH (which can induce insulin resistance via its diabetogenic domain), the 177-191 fragment does not impair glucose tolerance. The diabetogenic domain of hGH resides outside the 177-191 sequence.
What is the role of the disulfide bond in AOD-9604?
The Cys⁷–Cys¹⁴ disulfide bond is essential for the cyclic structure and biological activity. It constrains the peptide into the conformation required for β3-adrenergic receptor interaction. Verified by Ellman's test in every batch.
What purity specification applies to AOD-9604?
≥99% by HPLC at 214 nm with ESI-MS identity confirmation and Ellman's test for disulfide verification. Batch-specific COA included.
What is the difference between AOD-9604 and full-length HGH?
HGH (191 amino acids, ~22,125 Da) activates all GH receptor pathways including IGF-1 elevation and insulin resistance. AOD-9604 (16 amino acids, ~1,815 Da) is a precision fragment targeting only the lipolytic domain.
All products are manufactured for laboratory research purposes only. AOD-9604 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
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Bulk pricing, tiered discounts up to 30%, COA with every order.