FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Semaglutide Wholesale
31-amino acid GLP-1 receptor agonist — volume driver for metabolic portfolios, batch-documented, manufacturer-direct
Product Identity
| CAS Number | 910463-68-2 |
| Sequence | 31-amino acid with Aib⁸ (DPP-4 resistance) + C18 fatty diacid linker |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | ~4,113.6 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Phosphate buffer (pH 7.4); limited solubility in pure water |
| Storage | 2–8°C, desiccated, protect from light |
Factory-directShenzhen, China
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Most research protocols |
| Bulk Kit | 10 mg × 10 vials | High-throughput; OEM projects |
| Custom | Custom mg × custom vials | Private-label development |
Research Background
Semaglutide is a long-acting GLP-1 receptor agonist based on human GLP-1 (7-37). Two key modifications — Aib⁸ substitution for DPP-4 resistance and C18 fatty diacid linker for albumin binding — give it a ~7-day half-life, making it the most commercially significant peptide in the GLP-1 category.
Research Focus Areas
Glucose-dependent insulin secretion; glucagon suppression
Reduced food intake via hypothalamic GLP-1R; delayed gastric emptying
Reduced MACE in high-risk populations
Reduced albuminuria; slowed eGFR decline
Reduced liver fat; improved NASH resolution
Potential effects in Parkinson's and Alzheimer's models
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~4,113.6 ± 1.5 Da |
| Appearance | Visual | White to off-white powder |
| Peptide Content | AAA / elemental | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
| Linker Integrity | HPLC-ELSD / LC-MS/MS | Intact C18 linker (bulk orders) |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 10 mg × 10 vials | SM10 | US$42 |
| 20 mg × 10 vials | SM20 | US$66 |
| 30 mg × 10 vials | SM30 | US$85 |
US$42–85 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is the purity of Semaglutide?
≥99% by HPLC with ESI-MS confirmation. C18 fatty diacid linker integrity verified. Batch-specific COA included.
What is the molecular weight of Semaglutide?
~4,113.6 Da. The C18 fatty diacid linker at Lys26 is critical for albumin binding and extended half-life.
How does Semaglutide differ from Tirzepatide?
Semaglutide is a single GLP-1 receptor agonist. Tirzepatide is a dual GIP/GLP-1 agonist with enhanced metabolic effects. See our GLP-1 Buyer's Guide for full comparison.
What kit configurations are available?
Standard: 10mg × 10 vials. Also 5mg × 10 vials for evaluation orders. Custom configurations available for bulk wholesale orders.
How should Semaglutide be stored?
Lyophilized: 2-8°C, protected from light, 24-month stability. Reconstituted: aliquot at -20°C for up to 30 days. Do not refreeze.
What is the difference between Semaglutide sodium and Semaglutide acetate?
Different salt forms of the same peptide sequence. Sodium salt is produced by neutralizing TFA with NaOH; acetate by counterion exchange with acetic acid. Our standard is the sodium salt unless otherwise specified. Specify your salt form requirement in your inquiry.
Why is Semaglutide less soluble in pure water?
The C18 fatty diacid linker (lipidated side chain) makes Semaglutide more hydrophobic than non-lipidated peptides. Use phosphate buffer (pH 7.0–7.4) for reconstitution. Gentle vortexing may be needed — do not sonicate or heat, which can degrade the peptide or linker.
How do you verify the fatty acid linker is intact?
Standard HPLC (UV 214 nm) detects the peptide backbone but may not distinguish intact vs. degraded linker. For bulk orders we offer HPLC-ELSD or LC-MS/MS which specifically confirms intact lipidated peptide molecular weight.
Do you offer Cagrilintide + Semaglutide as a stack?
Yes — a standard pre-formulated specialty stack combining GLP-1 and amylin receptor agonism for dual-pathway metabolic research. Ships with combined COA. See Specialty Stacks or contact us.
All products are manufactured for laboratory research purposes only. Semaglutide is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country. GLP-1 receptor agonist analogues are prescription medicines in many jurisdictions — buyers must confirm the legal status of importation and possession, and hold any required authorisation.
Ready to Source Semaglutide?
Volume leader for metabolic portfolios. Tiered pricing up to 30% off. Custom annual contracts available.