Tirzepatide Wholesale
39-amino acid dual GIP/GLP-1 receptor agonist — the differentiation leader in metabolic peptide portfolios
Product Identity
| CAS Number | 2023788-19-2 |
| Sequence | 39-amino acid with Aib²+Aib¹³ + C20 fatty diacid linker + C-terminal amidation |
| Molecular Weight | ~4,813.5 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Phosphate buffer (pH 7.4) or dilute acetic acid |
| Storage | 2–8°C, desiccated, protect from light |
Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Most protocols; evaluation |
| Bulk Kit | 10 mg × 10 vials | High-throughput; OEM |
| Custom | Custom mg × custom vials | Private-label; protocol-specific |
Research Background
Tirzepatide is an "imbalanced" dual agonist — it activates both GIP and GLP-1 receptors but with ~5× greater GIPR potency. This dual mechanism is the basis for its enhanced metabolic efficacy over selective GLP-1 agonists.
Structural Features
Receptor Activity
| Parameter | GIP Receptor | GLP-1 Receptor |
|---|---|---|
| Binding Affinity (Ki) | ~2.3 nM | ~12.6 nM |
| Functional Activity (EC₅₀) | ~0.06 nM (cAMP) | ~0.03 nM (cAMP) |
| Relative Potency | ~5× more potent | Reference |
Research Focus Areas
~22.5% mean reduction (SURMOUNT-1); >GLP-1 alone
HbA1c reduction up to 2.4%; superior to Semaglutide 1mg
Improved lipid profiles; reduced triglycerides
Improved beyond weight loss alone (GIP-mediated)
Reduced liver fat content; under investigation for NASH
Tirzepatide vs Semaglutide vs Retatrutide
| Parameter | Semaglutide | Tirzepatide | Retatrutide |
|---|---|---|---|
| Receptor | GLP-1R | GIPR + GLP-1R | GIPR + GLP-1R + GCGR |
| Amino Acids | 31 | 39 | 39 |
| MW | ~4,113.6 Da | ~4,813.5 Da | ~4,845.5 Da |
| Linker | C18 | C20 | C20 |
| BW Reduction | ~15% | ~22.5% | ~24.2% (Ph2) |
| B2B Position | Volume leader | Differentiation | Innovation |
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~4,813.5 ± 1.5 Da |
| Appearance | Visual | White to off-white powder |
| Peptide Content | AAA / elemental | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
| Linker Integrity | HPLC-ELSD / LC-MS/MS | Intact C20 linker (bulk) |
Tirzepatide purification is more challenging than Semaglutide — 39 AA with closely related deletion peptides and oxidation products require optimized HPLC gradients.
Tiered Wholesale Pricing
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 2–5 kits | 10–20% off | Initial portfolio expansion |
| 6–20 kits | 25–40% off | Mid-size distributors |
| 21–50 kits | 40–55% off | Regional distributors |
| 50+ kits | 55–70% off | Large distributors; recurring |
FAQ
How does Tirzepatide differ from Semaglutide mechanistically?
Semaglutide activates only GLP-1R. Tirzepatide activates both GIPR and GLP-1R — the GIP component adds insulinotropic effects, improved lipid handling, and better insulin sensitivity. Read the full comparison in our GLP-1 Buyer's Guide →
Why is Tirzepatide more expensive than Semaglutide?
Three factors: longer sequence (39 vs 31 AA → more coupling steps, higher material costs), more challenging purification, and higher demand relative to capacity (Tirzepatide is in "differentiation" phase with growing demand).
What salt form is your Tirzepatide?
Standard is the acetate salt. If your protocol requires Na, TFA, or another counterion, specify in your inquiry — salt form can be adjusted during the final purification/lyophilization stage.
How do you confirm the identity — not just purity — of Tirzepatide?
Every batch undergoes both HPLC (purity, ≥99% peak area) AND ESI-MS (identity, confirming MW ~4,813.5 Da). For bulk orders: linker integrity by HPLC-ELSD or LC-MS/MS to confirm intact C20 fatty diacid conjugation.
FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary diagnostic, therapeutic, or any clinical use.
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Premium dual-agonist differentiation. Tiered pricing up to 70%. COA + MS + linker integrity with every bulk order.