FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
CJC-1295 (DAC) Wholesale
Long-acting GHRH analogue with Drug Affinity Complex — sustained GH pulse research, manufacturer-direct
Product Identity
| CAS Number | 863288-34-0 |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH₂ |
| Amino Acids | 30 (C-terminal DAC linker) |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular Weight | ~3,649.2 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 2 mg × 10 vials | GH pulse research; evaluation |
| Bulk Kit | 5 mg × 10 vials | Chronic GH axis studies; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label; protocol-specific |
Research Background
CJC-1295 is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) engineered with four amino acid substitutions that enhance receptor binding and proteolytic stability. The defining feature of the DAC (Drug Affinity Complex) variant is a maleimidopropionyl linker on the C-terminal lysine that covalently binds to Cys³⁴ of serum albumin — extending circulating half-life from ~7 minutes to ~8 days. For research protocols requiring chronic GH/IGF-1 axis activation, CJC-1295 with DAC is the tool of choice.
Proposed Mechanisms
Research Focus Areas
Sustained GHRH receptor activation → prolonged GH elevation
Lean mass preservation; fat mass reduction models
GH/IGF-1 axis-mediated anabolic signaling
Post-exercise GH pulse augmentation in trained models
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~3,649.2 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | CD5 | US$159 |
US$159–159 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is the DAC in CJC-1295?
DAC stands for Drug Affinity Complex — a maleimidopropionyl linker that covalently binds to Cys³⁴ of serum albumin. This conjugation extends half-life from minutes to ~8 days by preventing renal clearance and enzymatic degradation.
Difference between CJC-1295 with DAC and without DAC?
With DAC: ~8 day half-life → sustained GHRH activation → chronic GH/IGF-1. Without DAC: ~30 min half-life → discrete GH pulse → mimics endogenous pulsatile secretion. Choice depends on research objective.
Why pair CJC-1295 with Ipamorelin?
CJC-1295 amplifies the GHRH signal (the 'on' switch). Ipamorelin suppresses somatostatin tone (the 'off' switch). Together they produce a larger net GH pulse than either alone — well-characterized synergism.
How should CJC-1295 (DAC) be stored?
Lyophilized: 2–8°C, desiccated, 24-month stability. After reconstitution, store at 2–8°C. The DAC-albumin conjugate forms spontaneously — this is expected and part of the molecule's designed mechanism.
What configurations are available?
Standard: 2mg × 10 vials. Bulk: 5mg × 10 vials. Custom mg/vial for OEM/private-label. CJC-1295 (no DAC) also available as a separate SKU for pulsatile GH protocols.
All products are manufactured for laboratory research purposes only. CJC-1295 (DAC) is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source CJC-1295 (DAC)?
Bulk pricing, tiered discounts up to 30%, COA with every order.