FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
Argireline vs SNAP-8
Argireline and SNAP-8 are the two most-cited members of the SNAP-25 N-terminal mimetic family used in vesicle-docking research. They carry the same N-terminal hexapeptide motif; SNAP-8 extends it by two residues. The practical difference in an assay is chain length and its physicochemical consequences — not a different mechanism class.
Side-by-side comparison
| Parameter | Argireline | SNAP-8 |
|---|---|---|
| INCI-style description | Acetyl hexapeptide-8 | Acetyl octapeptide-3 |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Residues | 6 | 8 |
| Listed molecular weight (catalogue) | ~889.0 Da | ~1,073.2 Da |
| Terminal modifications | N-acetyl, C-amide | N-acetyl, C-amide |
| Mechanism class | Structural interference with SNARE ternary-complex assembly (SNAP-25 N-terminal mimicry) | Same mechanism class, longer chain |
| Typical assay role | Reference hexapeptide in SNARE-assembly and vesicle-docking readouts | Length variant used to probe how chain extension changes the readout |
Sequences and terminal modifications as listed in the catalogue. Mechanism class described from the published SNAP-25 N-terminal mimetic literature. No efficacy or cosmetic claim is made.
How to choose between them
Use the pair as a structure–activity series, not as substitutes
Running both peptides in the same SNARE-assembly assay isolates the effect of the two-residue extension. If you only need one, match the chain length to the published series your protocol cites.
Expect different solution behaviour
The additional Ala-Asp residues change net charge and size, so solubility, filtration behaviour and analytical retention differ. Neither peptide has protease activity: competition, not cleavage, is the mechanism under study.
Check the terminal protecting groups on the COA
Both molecules are N-acetylated and C-amidated. An unmodified fragment is a different material with different stability, so the terminal groups belong in your identity confirmation.
Products in this comparison
| Product | List price (per kit of 10 vials) |
|---|---|
| Argireline | Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) |
| SNAP-8 | US$45–45 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
| Leuphasyl | Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) |
| Matrixyl | Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) |
| AHK-Cu | US$45–58 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) |
FAQ
How do Argireline and SNAP-8 differ structurally?
Argireline is the six-residue N-terminal motif Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂. SNAP-8 carries the same motif extended by Ala-Asp, for eight residues and roughly 184 Da more mass.
Do they act through the same mechanism?
They are studied as structural competitors in the same SNARE-complex-assembly assay system. The difference is chain length, not mechanism class — which is exactly why they are useful as a comparative pair.
Are these cosmetic ingredients?
No claim of cosmetic or human application is made for these listings. They are supplied as laboratory research peptides with a batch-specific COA, for in vitro research use only.
Is Argireline on the published price list?
Argireline is one of a small number of catalogue peptides not listed on the current wholesale price list, so its kit price is quoted on request within the published catalogue band. SNAP-8 has a fixed list price on the price list.
Need a quote for this group?
Component specifications, batch COAs and volume pricing for the whole cluster — quoted within one business day.