FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
DSIP Wholesale
Delta sleep-inducing peptide nonapeptide — sleep architecture & circadian rhythm research, manufacturer-direct
Product Identity
| CAS Number | 62568-57-4 |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH |
| Amino Acids | 9 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | ~848.8 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Sleep research; evaluation |
| Bulk Kit | 10 mg × 10 vials | Chronic sleep models; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
DSIP (Delta Sleep-Inducing Peptide) was first isolated from rabbit cerebral venous blood during electrically-induced sleep in the 1970s by Monnier and Schoenenberger. The isolated nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) was found to induce slow-wave (delta) sleep. Subsequent research expanded its profile beyond sleep: it modulates the HPA stress axis, produces opioid-independent analgesia, and influences circadian regulation.
Proposed Mechanisms
Research Focus Areas
Slow-wave sleep enhancement; sleep efficiency improvement
Sleep-wake cycle regulation in jet lag and shift work models
ACTH and corticosterone modulation under stress conditions
Opioid-independent analgesic effects in chronic pain models
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~848.8 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Peptide Content | Amino acid analysis | ≥80% net peptide |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | DS5 | US$40 |
| 15 mg × 10 vials | DS15 | US$93 |
US$40–93 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is Delta Sleep-Inducing Peptide (DSIP)?
DSIP is a naturally occurring nonapeptide first isolated from rabbit cerebral blood during induced slow-wave sleep. It promotes delta wave (0.5–4 Hz) EEG activity characteristic of deep, restorative sleep. Also modulates HPA stress axis and produces opioid-independent analgesia.
How was DSIP discovered?
Discovered in the 1970s by Monnier and Schoenenberger, who electrically stimulated rabbit thalamus to induce sleep, collected cerebral venous blood, and isolated the factor that transferred sleep-inducing activity to recipient animals. Identified as the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Does DSIP work through opioid receptors?
No — a key research distinction. DSIP produces analgesic effects but does not bind μ, δ, or κ opioid receptors. Its analgesic mechanism involves central serotonin and GABA pathways. This opioid-independent pain modulation makes it a unique research tool.
How does DSIP compare to melatonin for sleep research?
Melatonin primarily regulates sleep timing (circadian phase shifting). DSIP primarily affects sleep depth (delta wave promotion). Different aspects of sleep physiology — can be studied in complementary protocols.
What purity and QC is provided for DSIP?
≥99% HPLC with ESI-MS identity. Trp¹ residue monitored for oxidation. Batch-specific COA included. Full analytical documentation for bulk orders.
All products are manufactured for laboratory research purposes only. DSIP is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.