FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
PEG-MGF Wholesale
PEGylated IGF-1Ec splice variant — muscle stem cell (satellite cell) activation research, manufacturer-direct
Product Identity
| CAS Number | — (IGF-1Ec splice variant, PEGylated) |
| Sequence | IGF-1Ec E-domain peptide (24-aa insert), PEGylated |
| Amino Acids | ~94 + PEG moiety |
| Molecular Weight | ~11,500 Da (PEG-protein conjugate) |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile water or PBS |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 1 mg × 10 vials | Satellite cell research; evaluation |
| Bulk Kit | 2 mg × 10 vials | Muscle regeneration protocols; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
PEG-MGF (PEGylated Mechano Growth Factor) is a modified form of IGF-1Ec — the splice variant of IGF-1 preferentially expressed in skeletal muscle in response to mechanical load. MGF differs from systemic IGF-1 by a 24-amino acid C-terminal E-domain insert that confers distinct receptor binding and specifically activates muscle satellite (stem) cells. PEGylation extends the peptide's half-life from minutes to ~24 hours, making it viable for chronic muscle regeneration research.
Proposed Mechanisms
Research Focus Areas
Muscle stem cell proliferation and differentiation
Post-damage myofiber repair and hypertrophy models
Age-related muscle stem cell depletion countermeasures
Mechanical load-induced MGF expression simulation
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | MALDI-TOF MS | ~11,500 ± 500 Da |
| Appearance | Visual inspection | White to off-white powder |
| PEGylation | SDS-PAGE | Band shift confirmed |
| Endotoxin | LAL assay | ≤0.5 EU/mg |
Tiered Wholesale Pricing
Kit prices are quoted per specification — current list prices for peptide kits run from US$24 to US$339 per kit (10 vials); tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
What is Mechano Growth Factor (MGF)?
MGF is the IGF-1Ec splice variant expressed locally in skeletal muscle following mechanical load or damage. It contains a 24-amino acid E-domain that targets muscle satellite cells specifically. The 'mechano' prefix refers to its induction by mechanical stress.
Why is PEGylation necessary for MGF?
Native MGF has a very short half-life (minutes). PEGylation increases hydrodynamic radius, reduces renal clearance, and extends half-life to ~24 hours. Without PEGylation, MGF would not be viable for most research protocols.
How does MGF differ from standard IGF-1?
(1) MGF is a local splice variant expressed in muscle, not liver-derived; (2) the E-domain insert confers satellite cell receptor specificity; (3) MGF's primary role is stem cell activation/myoblast proliferation, while systemic IGF-1 primarily drives protein synthesis in mature myofibers.
What research applications use PEG-MGF?
Satellite cell (muscle stem cell) biology, muscle regeneration/repair following injury models, sarcopenia research, and exercise physiology studies exploring the MGF response to mechanical loading.
What QC is unique to PEG-MGF?
Beyond standard HPLC and MS: SDS-PAGE confirms PEGylation band shift; LAL endotoxin testing; NMR or colorimetric PEG verification. All in batch-specific COA.
All products are manufactured for laboratory research purposes only. PEG-MGF is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
Ready to Source PEG-MGF?
Bulk pricing, tiered discounts up to 30%, COA with every order.