FOR LABORATORY RESEARCH USE ONLY — not for human or veterinary use, diagnosis, treatment, or cosmetic application. Buyers must be 21+ and legally permitted to purchase research chemicals in their jurisdiction.Intended-use statement →
GHRP-6 Wholesale
Growth Hormone Releasing Peptide-6 — strong GH pulse with pronounced hunger signaling, manufacturer-direct
Product Identity
| CAS Number | 87616-84-0 |
| Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ |
| Amino Acids | 6 (D-Trp², D-Phe⁵) |
| Molecular Formula | C₄₆H₅₆N₁₂O₆ |
| Molecular Weight | ~873.0 Da |
| Appearance | White to off-white lyophilized powder |
| Purity | ≥99% by HPLC |
| Solubility | Soluble in sterile or bacteriostatic water |
| Storage | 2–8°C, desiccated, protect from light |
Available Configurations
| Configuration | Content | Best For |
|---|---|---|
| Standard Kit | 5 mg × 10 vials | Ghrelin pathway research; evaluation |
| Bulk Kit | 10 mg × 10 vials | Chronic protocols; repeat orders |
| Custom | Custom mg × custom vials | OEM; private-label |
Research Background
GHRP-6 is the prototypical synthetic ghrelin receptor agonist — and the most orexigenic member of the GHRP family. Its hexapeptide sequence (His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂) closely mimics the N-terminal active core of ghrelin, producing potent activation of both the GH-releasing and appetite-stimulating arms of GHS-R1a signaling.
Proposed Mechanisms
Research Focus Areas
Potent pituitary GH secretion via ghrelin receptor activation
Strong orexigenic (hunger-promoting) signaling — ghrelin pathway studies
Ghrelin-mediated GI motility and gastric emptying research
GH/IGF-1 mediated anabolic effects with appetite co-stimulation
Quality Specifications
| Parameter | Method | Criterion |
|---|---|---|
| Purity | HPLC at 214 nm, C18 column | ≥99.0% peak area |
| Identity (MW) | ESI-MS | ~873.0 ± 1.0 Da |
| Appearance | Visual inspection | White to off-white powder |
| Chiral Purity | Chiral HPLC | D-Trp², D-Phe⁵ verified |
| Residual Moisture | Karl Fischer | ≤3% |
Tiered Wholesale Pricing
| Kit size | Code | List price |
|---|---|---|
| 5 mg × 10 vials | G65 | US$42 |
| 10 mg × 10 vials | G610 | US$69 |
US$42–69 per kit (10 vials), from our published wholesale price list; tiered volume discounts apply (see the tier table) — source:wholesale price list (PDF, updated 2026-08-08).
| Volume | Discount | For |
|---|---|---|
| 1 kit | List price | Evaluation; competitive analysis |
| 5+ kits | 10% off | Initial portfolio expansion |
| 20+ kits | 20% off | Mid-size distributors |
| 50+ kits | 30% off | Regional distributors |
FAQ
Why does GHRP-6 increase hunger so strongly?
GHRP-6 is the closest structural mimetic to ghrelin's N-terminal active core. Its activation of GHS-R1a in the hypothalamic arcuate nucleus strongly stimulates NPY/AgRP neurons — the most potent orexigenic neurons in the brain.
How does GHRP-6 compare to GHRP-2?
Both are potent GHS-R1a agonists, but GHRP-6 produces stronger hunger signaling due to closer structural homology to ghrelin. GHRP-2 has modifications (D-Ala¹, D-2-Nal²) that shift toward purer GH release with less appetite stimulation.
Is GHRP-6 suitable for all GH research?
It depends on protocol. GHRP-6 is the tool of choice when studying ghrelin's dual GH-releasing and appetite-stimulating effects. When appetite is a confounding variable, Ipamorelin (minimal hunger) or GHRP-2 (moderate hunger) should be considered.
What is the structural basis of GHRP-6 activity?
D-Trp² and D-Phe⁵ residues are critical for GHS-R1a binding and stability. His¹ mimics ghrelin's N-terminal serine-3 acylation site. Together these enable nanomolar potency while resisting degradation.
How should GHRP-6 be stored?
Lyophilized: 2–8°C, desiccated, 24-month stability. Reconstitute, aliquot, store at -20°C. D-amino acid modifications provide good solution stability. Protect from freeze-thaw cycles.
All products are manufactured for laboratory research purposes only. GHRP-6 is labeled FOR LABORATORY RESEARCH USE ONLY. Not for human or veterinary use, diagnosis, treatment, prophylaxis or any clinical, cosmetic, dietary or household application. Not a dietary supplement, pharmaceutical ingredient, cosmetic ingredient or approved drug substance. Buyers are responsible for verifying the legal status of importation and possession in their destination country.
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Bulk pricing, tiered discounts up to 30%, COA with every order.